The Discovery By a Pakistani Doctor Might Help to cure Dementia


It’s a worst thought to see someone who you’ve known and relied on for most of your life, exhibiting signs of forgetfulness. Once, you think they may have made an honest mistake by forgetting the car keys. And then, as you see this same scenario playing out again , you fear that the worst case scenario is already here. A disease like Alzheimer’s, which falls under Dementia, has well and truly become a part of your life from moment onwards.

For many time, there has been no true cure for dementia. Modern medicine has failed in this respect.

But now, a recent discovery by a team of neuroscientists may turn the tide against neurodegenerative diseases like Alzheimer’s.

As your age, your progressive memory starts to decline, leading to dementia.

A New real Hope

A Switzerland-based Pakistani neuroscientist, as well as his team members, have discovered a pathway in the human brain that helps explain memory loss associated with age and dementia.

Dr Ali Jawaid, MD PhD, at the Mansuy lab in the Swiss Federal Institute of Technology, has demonstrated a way to stop to memory impairment in dementia disorders.  In short, the reversal of memory loss is much possible.

How Does the Cure Work???

Before we get to this, it is important to understand how Dementia is caused. This progressive neurodegenerative disorder occurs due to the accumulation of toxic senile amyloid plaques and neurofibrillary tangles in your brain. These toxic proteins end up causing synaptic and neuron loss in their victims.

Dr Ali and his co-workers have discovered a molecular pathway through which these toxic proteins block memories. A small cluster of regulatory molecules, need to do their duty without any hurdles in their way. It is these RNAs whose production is impaired in patients who suffer from dementia, thus causing a blockade on memory retention.

A MicroRNA

Toxic proteins, which accumulate in your brain, with old age or in neurodegenerative conditions, amyotrophic lateral sclerosis (the ice bucket disease) or frontotemporal dementia (second most cause of dementia after Alzheimer disease) impair the production of these microRNAs.

About Dr Ali :

Dr Ali has studied in the Agha Khan University of  Karachi. He has also received training from Baylor College of Medicine, Texas, USA and University of Zurich. He has taught Neuroscience at the Biology Department in LUMS as a visiting faculty and chairs the European MD-PhD Associations. His scientific credentials include two doctoral degrees, and a tally of 60 scholarly papers in top-notch scientific journals; Nature Neuroscience, Nature Communications, Molecular Neurobiology, and Science.

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Arooj Fatima


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